A New Approach To Alzheimer’S Disease Can Return The Memory To Patients

Medicine

Alzheimer’s disease occurs as a result of genetic and environmental risk factors, which, together, lead to epigenetic changes that affect the expression of genes, however, as it is happening, scientists do not yet know.A New Approach To Alzheimer’S Disease Can Return The Memory To Patients
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Employees of the University of Buffalo found that, focusing on changes in genes caused by epigenetics, it is possible to draw the process of reducing memory in mice with this disease. The results of their work are published in the brain magazine.

"In his study, we not only identified the epigenetic factors that contribute to the loss of memory, but also found methods to temporarily turn them into an animal model with Alzheimer’s disease," says Senior author of Zhen Yan (Zhen Yan).

According to Yana, epigenetic changes in this disease occur mainly at the later stages, when patients cannot preserve the recent information and demonstrate the most sharp decrease in cognitive functions. The main cause of this process, scientists consider the loss of glutamate receptors, which are crucial for short-term memory. The researchers found that in Alzheimer’s disease, subunit of these receptors are suppressed that negatively affects cognitive abilities. In addition, it turned out that their loss – the result of the epigenetic process known as the repressive modification of histones, which increases with the disease.

"This anomalous histone modification associated with Alzheimer’s disease suppresses gene expression, reducing glutamate receptors, which leads to a memory shortage. In Your Study, We Show How this Cognitive Dysfunction Can Be Corrected by Sending Epigenetic Enzymes to Restore Glutamate Receptors, "Explains The Scientist.

In The Course of An Experiment, An An Animal With Alzheimer’s Disese Was Injected Three Times The Drugs Needed to Inhibit That Enzyme, Which Is Responsible for The Repressive Modification of Histones. As A Result, Researchers Were Surprised to Find That The Indicators of the Memory of Recognition, Spatial and Working Memory Improved. However, The Observed Effect Lasted Just A Week, So Future Studies Will Focus On The Development Of Compounds That Penetrate The Brain More Efficiently and Thus, Act Longer.

"In our work, we showed that the specific epigenetic regulation of expression and the glutamate receptor function did contribute to a decrease in cognitive functions in Alzheimer’s disease, and now, knowing it, we approached the restoration of some cognitive functions," the scientist summarizes.

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