An Enzyme Is Opened, Able To Stop Cell Death


Biochemists from RUDN found that apoptosis (programmed cell death) can be adjusted using ENDOG enzyme. Opening will lead to a better understanding of cell protection mechanisms and tissues.An Enzyme Is Opened, Able To Stop Cell Death
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Defective cells (i.e. infected or mechanically damaged) are destroyed in the process of apoptosis – adjustable cell death. Thanks to this cells are constantly updated. In the body of a healthy person in the process of apoptosis, up to 70 billion cells are destroyed. If the process changes – accelerates or slows down, this leads to oncological, autoimmune, neurodegenerative and other diseases.

There are several enzymes called apoptotic endonucleases and participating in the programmed cell death. RUDN biochemists demonstrated that one of them is ENDOG – can stop the process of death of cells if it comes out of control. IT TURNED OUT THAT THE INCREASED SECRETTION OF ENDOG LOWERS THE VOLUME OF ANOTHER ENDONUCLEASE CALLED DEOXYRIBONUCLEASE I (DNAZ I) and SLOWS DOWN THE PROCESS OF APOPTOSIS AT THE EARLY STAGE. Two Enzymes SHOLD INITIALLY WORK TOGETHER, THAT IS, SIMULTANEUSLY AFFECT THE DNA OF THE DESTROY IT. Biochemists from Rudn Became The First to Demonstrate That Endog and Dunk i, in Fact, Rather Rivals Than Comrades. THE RESULTS OF THE STUDY ARE PUBLISHED IN BOYCHIMIE MAGAZINE.

"Enzyme Endog Works As A Protective Mechanism AGAINST DNASE I AND DNA DESTRUCTION. In This Case, The Mechanism of Cell Death Turns Out to Be: Endog, Destroying DNA Enzyme, Can Stop Apoptosis IF It Proceeds Very Quickly or Goes Too Far, "Says Dmitry Zhdanov, Co-Author of Research and Candidate of Biological Sciences From Rudn.

For Experimental Research, Scientists from Rudn USED Blood 50 People From 18 To 25 Years Worthood Diagnosed Diseases. Researchers Provoked An Increase In Endog Synthesis In Donor T-Lymphocytes. THEN, WITH THE HELP OF A DESTRUCTIVE DNA Substance Called Bleomycin, The Process of Apoptosis Was Launched in Cells and Measured Endog and Dnases I Measured. IT TURNED OUT THAT EXCESS ENDOG LOWERS THE LEVEL OF DNASE I, AND THEREFORE SLOWS DOWN THE ENTIRE PROCESS OF APOPTOSIS.

"We Were The Negative Ratio Between Endog and Dunka I. This Discovery Can Help Adjust The Cell Response to Any Damage, And Endog Activation Can Be a Protective Mechanism from Uncontrolled Cell Death, "Adds Zhdanov.

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