Scientists from Oregon University found out that the NRF2 protein, oppressable by molecules of microg-146a, is responsible for the "breakdown" in a genetic connection that causes syndromes associated with aging in the human body.
As Xinhua writes, NRF2 protein traditionally plays a decisive role in restoring tissues and protection against malignant neoplasms. In the study of the University of Oregon University, published in the magazine Free Radical Biology and Medicine, scientists describe this protein at the same time as the "monitor" and "transmitter". It monets the metabolic problems in the body, responding to toxins, oxidative stress and other. Receiving a problem, the protein can "include" up to 200 genes, "repairing" cells.
With age, NRF2 activity decreases. According to scientists, in the elderly laboratory animals, its level is 30-40% lower than their young fellow. And responsible for this decrease in molecule microg-146a.
These molecules are quite well known and perform an important function in the body, similar to that which NRF2 is responsible for. For example, they activate the inflammatory process, preventing the spread of infection and contributing to healing. And the level of them with age, on the contrary, increases. "With age, the molecule ceases to work properly, reducing the level of NRF2 in the body. That is, the action of microg-146a is no longer beneficial, but at the detriment, "scientists explained. In particular, as a result of this failure, people develop various chronic inflammatory processes leading to heart diseases, oncology and other illnesses. To prevent this, scientists have to find out how to keep the balance between NRF2 and MICRORNAK-146A.