Scientists from the University of California in San Francisco found out that two common variations of genes, which lead to the elongation of telomere, significantly increase the risk of brain cancer.
TELUMERS – End plots chromosomes. Teomeric sections with chromosomes are characterized by the lack of ability to connect with other chromosomes or their fragments and perform a protective function. We are talking about TERT and TERC genes, which are available in 51% and 72% of the inhabitants of the planet, respectively, however, their variations are very rare.
There is a high barrier interfering with Guli’s development, and maybe because the brain has a special defense.
– Margaret Vrench, Head of the Department of Studies of Brain Tumors and the main author of the new research
TERT and TERC genes are responsible for elongation telomere. However, as Vrench notes, it has both positive qualities and negative. Long telomers not only respond to longevity, but also lead to the development of glioma.
Glyoma – a tumor, which is included in the heterogeneous group and having neuroectodermal origin. This is the most common primary a brain tumor.
Although longer telomeres can be a good fact for a person, reducing some health risks and slowing aging, but they can also lead to the fact that some cells live longer laid, and this is supposed to be a sign of cancer development.
– Kyle M. Walsh, Associate Professor of the Department of Neurological Surgery
In the course of the study, scientists conducted an analysis of the genomic base of almost 40 thousand people. They found that short telomers are associated with cardiovascular diseases.
Vrench together with colleagues investigated 1644 patients suffering from glioma, and 7736 healthy people. As a result, most patients with glioma were found variations of TERT and TERC genes, as well as increased telomers.
Scientists have to continue the study and explore the effect of the TERT gene in the development of lung cancer, prostate, breast, as well as leukemia and colon cancer.